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KMID : 0604520100360030175
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Journal of the Society of Cosmetic Scientists of Korea
2010 Volume.36 No. 3 p.175 ~ p.182
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Antioxidant Activity and Whitening Effect of Cedrela sinensis A. Juss Shoots Extracts
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Kim Sun-Young
Kim Chae-Rin
Kim Hyun-Min
Kong Myung
Lee Ji-Hee
Lee Hyun-Jun
Lim Myoung-Sun
Jo Na-Rae
Park Soo-Nam
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Abstract
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In this study, the antioxidative effects, inhibitory effects on tyrosinase of Cedrela sinensis extracts were investigated. The ethyl acetate fraction of extract () and aglycone fraction of extract () showed more excellent free radical (1,1-diphenyl-2-picrylhydrazyl, DPPH) scavenging activity () than the activity of (+)--tocopherol (). Reactive oxygen species (ROS) scavenging activities () of Cedrela sinensis extracts on ROS generated in -EDTA/ system were investigated using the luminol-dependent chemiluminescence assay. The ethyl acetate fraction of extract () and aglycone fraction of extract () showed 10 times more excellent ROS scavenging activity than activity of L-ascorbic acid (). The protective effects of fractions of Cedrela sinensis on the rose-bengal sensitized photohemolysis of human erythrocytes were investigated. The ethyl acetate fraction of extract and aglycone fraction of extracts suppressed photohemolysis in a concentration dependent manner (). The inhibitory effect of Cedrela sinensis extracts on tyrosinase was investigated to assess their whitening efficacy. Inhibitory effects () on tyrosinase were determined with ethyl acetate fraction of Cedrela sinensis extract () and aglycone fraction of extract (). The aglycone fraction showed 40 times more remarkable tyrosinase inhibitory effect than whitening agent, arbutin () These results indicate that fractions of Cedrela sinensis can be used as antioxidants in biological systems, particularly skin exposed to UV radiation by scavenging and other ROS, and protect cellular membranes against ROS. The fractions of Cedrela sinensis can be applicable to new functional cosmetics for antioxidant and whitening.
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KEYWORD
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Cedrela sinensis, antioxidative activity, whitening effect, flavonoids, cosmetics
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